For an oocyte to be All set for fertilization and expansion into an embryo, the appropriate set of genes ought to be turned on. Namekawa suspected that this pre-programming from the oocyte genome happens in many stages — the first one particular starting across the time a feminine is born. He believed that chromatin remodeling proteins did Substantially of this work, by shifting spools about.

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Using the GCRLE grant, Munakata and Namekawa will look a lot more carefully at how oocytes are genomically primed and saved for afterwards use. They'll examine the purpose of the chromatin remodeler in oocyte survival and fertility.

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